ethyl 3-(1-benzenesulfonylindol-3-yl)-2-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}-3-oxopropanoate

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Chemical Name:ethyl 3-(1-benzenesulfonylindol-3-yl)-2-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}-3-oxopropanoate
CAS No.:866270-16-8
Molecular Formula:C₃₃H₃₈N₄O₉S
Molecular Weight:666.752
Hs Code.:

Synonyms:ethyl 3-(1-benzenesulfonylindol-3-yl)-2-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}-3-oxopropanoate

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Chemical Property of ethyl 3-(1-benzenesulfonylindol-3-yl)-2-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}-3-oxopropanoate

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Technology Process of ethyl 3-(1-benzenesulfonylindol-3-yl)-2-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}-3-oxopropanoate

There total 4 articles about ethyl 3-(1-benzenesulfonylindol-3-yl)-2-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 862538-65-6
ethyl 3-(1-benzenesulfonylindol-3-yl)-2-diazo-3-oxo-propanoate

: 866270-14-6
(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-methyloxazole-4-carboxamide

: 866270-16-8
ethyl 3-(1-benzenesulfonylindol-3-yl)-2-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}-3-oxopropanoate

: ethyl 2-(1-benzenesulfonylindol-3-yl)-N-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}malonate

Guidance literature:: With rhodium (II) octanoate dimer; In dichloromethane; Heating;
DOI:10.1021/jo0509760

Reference yield:

: 35150-08-4
Boc-Val-NH₂

: 866270-16-8
ethyl 3-(1-benzenesulfonylindol-3-yl)-2-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}-3-oxopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / dirhodium tetraoctanoate / CH₂Cl₂ / Heating

2: 89 percent / triphenylphosphine; iodine; Et₃N / CH₂Cl₂

3: 99 percent / NH₃ / methanol

4: 12 percent / dirhodium tetraoctanoate / CH₂Cl₂ / Heating

With rhodium (II) octanoate dimer; ammonia; iodine; triethylamine; triphenylphosphine; In methanol; dichloromethane; 2: Robinson-Gabriel cyclodehydration reaction / 4: Wolff rearrangement;
DOI:10.1021/jo0509760

Reference yield:

: 159830-04-3
2-<(S)-1--2-methylpropyl>-5-methyl-4-carbomethoxyoxazole

: 866270-16-8
ethyl 3-(1-benzenesulfonylindol-3-yl)-2-{[(1-tert-butoxycarbonylamino-2(S)-methylpropyl)-4-methyloxazole-5-carbonyl]amino}-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / NH₃ / methanol

2: 12 percent / dirhodium tetraoctanoate / CH₂Cl₂ / Heating

With rhodium (II) octanoate dimer; ammonia; In methanol; dichloromethane; 2: Wolff rearrangement;
DOI:10.1021/jo0509760