2-[(3-benzyloxy-propoxymethyl)-ethoxy-phosphinoylmethyl]-acrylic acid methyl ester

Base Information

• Chemical Name: 2-[(3-benzyloxy-propoxymethyl)-ethoxy-phosphinoylmethyl]-acrylic acid methyl ester
• CAS No.: 356785-82-5
• Molecular Formula: C₁₈H₂₇O₆P
• Molecular Weight: 370.383
• Mol file: 356785-82-5.mol

Synonyms:2-[(3-benzyloxy-propoxymethyl)-ethoxy-phosphinoylmethyl]-acrylic acid methyl ester

Chemical Property of 2-[(3-benzyloxy-propoxymethyl)-ethoxy-phosphinoylmethyl]-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(3-benzyloxy-propoxymethyl)-ethoxy-phosphinoylmethyl]-acrylic acid methyl ester

There total 4 articles about 2-[(3-benzyloxy-propoxymethyl)-ethoxy-phosphinoylmethyl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl 2-(bromomethyl)propenoate (4224-69-5) + (3-benzyloxy-propoxymethyl)-phosphinic acid ethyl ester (356785-81-4) → 2-[(3-benzyloxy-propoxymethyl)-ethoxy-phosphinoylmethyl]-acrylic acid methyl ester (356785-82-5)

Guidance literature:

(3-benzyloxy-propoxymethyl)-phosphinic acid ethyl ester; With chloro-trimethyl-silane; TEA;

methyl 2-(bromomethyl)propenoate; at 0 - 20 ℃; for 2h;

DOI:10.1016/S0960-894X(01)00251-7

Reference yield:

3-benzyloxypropan-1-ol (4799-68-2) → 2-[(3-benzyloxy-propoxymethyl)-ethoxy-phosphinoylmethyl]-acrylic acid methyl ester (356785-82-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / HCl

2.1: 29 percent / 2,6-lutidine; BSA / acetonitrile / 1 h / 90 °C

3.1: 97 percent / TMSCl; H₂O / CHCl₃ / 5 h / 20 °C

4.1: TEA; TMSCl

4.2: 83 percent / 2 h / 0 - 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; benzenesulfonamide; chloro-trimethyl-silane; TEA; water; In chloroform; acetonitrile; 2.1: Arbuzov reaction / 4.2: Arbuzov reaction;

DOI:10.1016/S0960-894X(01)00251-7

Reference yield:

(3-Chloromethoxy-propoxymethyl)-benzene (127684-87-1) → 2-[(3-benzyloxy-propoxymethyl)-ethoxy-phosphinoylmethyl]-acrylic acid methyl ester (356785-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 29 percent / 2,6-lutidine; BSA / acetonitrile / 1 h / 90 °C

2.1: 97 percent / TMSCl; H₂O / CHCl₃ / 5 h / 20 °C

3.1: TEA; TMSCl

3.2: 83 percent / 2 h / 0 - 20 °C

With 2,6-dimethylpyridine; benzenesulfonamide; chloro-trimethyl-silane; TEA; water; In chloroform; acetonitrile; 1.1: Arbuzov reaction / 3.2: Arbuzov reaction;

DOI:10.1016/S0960-894X(01)00251-7

upstream raw materials:

methyl 2-(bromomethyl)propenoate

(3-benzyloxy-propoxymethyl)-phosphinic acid ethyl ester

3-benzyloxypropan-1-ol

(3-Chloromethoxy-propoxymethyl)-benzene

Downstream raw materials:

3-{[3-(diphenoxy-phosphoryloxy)-propoxymethyl]-ethoxy-phosphinoyl}-2-methyl-propionic acid methyl ester