(2R,6S)-2-(3,4-dimethoxyphenyl)-6-(4-methoxyphenethyl)tetrahydro-2H-pyran

Base Information

Chemical Name:(2R,6S)-2-(3,4-dimethoxyphenyl)-6-(4-methoxyphenethyl)tetrahydro-2H-pyran
CAS No.:1451998-94-9
Molecular Formula:C₂₂H₂₈O₄
Molecular Weight:356.462
Hs Code.:

Synonyms:(2R,6S)-2-(3,4-dimethoxyphenyl)-6-(4-methoxyphenethyl)tetrahydro-2H-pyran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,6S)-2-(3,4-dimethoxyphenyl)-6-(4-methoxyphenethyl)tetrahydro-2H-pyran

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Technology Process of (2R,6S)-2-(3,4-dimethoxyphenyl)-6-(4-methoxyphenethyl)tetrahydro-2H-pyran

There total 24 articles about (2R,6S)-2-(3,4-dimethoxyphenyl)-6-(4-methoxyphenethyl)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1451998-90-5
2-((2S,6R)-6-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-2-yl)-1-(4-methoxyphenyl)ethanone

: 1451998-94-9
(2R,6S)-2-(3,4-dimethoxyphenyl)-6-(4-methoxyphenethyl)tetrahydro-2H-pyran

Guidance literature:: 2-((2S,6R)-6-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-2-yl)-1-(4-methoxyphenyl)ethanone; With sodium tetrahydroborate; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1h;

With triethylsilane; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1h;
DOI:10.1002/ejoc.201300097

Reference yield:

: C₂₂H₂₇BrO₄

: 1451998-94-9
(2R,6S)-2-(3,4-dimethoxyphenyl)-6-(4-methoxyphenethyl)tetrahydro-2H-pyran

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 24h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2021.132375

Reference yield:

: 1451998-82-5
(S)-1-(3,4-dimethoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-one

: 1451998-94-9
(2R,6S)-2-(3,4-dimethoxyphenyl)-6-(4-methoxyphenethyl)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / methanol / 4 h

2.1: toluene-4-sulfonic acid; methanol / 4 h / Inert atmosphere

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: sodium iodide / acetone / 12 h / Reflux; Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

5.2: 2 h / 20 °C

6.1: copper(ll) sulfate pentahydrate; water / methanol / 1.5 h / 60 °C

7.1: sodium tetrahydroborate / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C

7.2: 1 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; copper(ll) sulfate pentahydrate; water; sodium hydride; toluene-4-sulfonic acid; triethylamine; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1002/ejoc.201300097