Technology Process of tert-butyl 8-(3-methoxyphenyl)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate
There total 8 articles about tert-butyl 8-(3-methoxyphenyl)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
1,2-dimethoxyethane; water;
at 85 ℃;
for 1.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: borane-THF / tetrahydrofuran / 1 h / 0 - 65 °C
1.2: 16 h / 0 - 65 °C / pH 2
1.3: 0 °C
2.1: sodium hydroxide / water; tetrahydrofuran / 1.5 h / 10 - 30 °C
3.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1.5 h / 85 °C / Inert atmosphere
With
borane-THF; potassium carbonate; sodium hydroxide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1,2-dimethoxyethane; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C
2.1: trifluoroacetic acid / 0.33 h / 10 - 30 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxybenzotriazole ammonium salt / N,N-dimethyl-formamide / 1.5 h / 10 - 30 °C
4.1: potassium carbonate; water / methanol / 1.5 h / 65 °C
4.2: pH 1
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 10 - 30 °C
6.1: borane-THF / tetrahydrofuran / 1 h / 0 - 65 °C
6.2: 16 h / 0 - 65 °C / pH 2
6.3: 0 °C
7.1: sodium hydroxide / water; tetrahydrofuran / 1.5 h / 10 - 30 °C
8.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1.5 h / 85 °C / Inert atmosphere
With
N-hydroxybenzotriazole ammonium salt; borane-THF; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
![tert-butyl 8-bromo-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate](/Databaselist/images/loading.webp)
