Technology Process of (+/-)-1-benzyl-3-oxo-4-(cyclohexyl)-2-azetidinone
There total 11 articles about (+/-)-1-benzyl-3-oxo-4-(cyclohexyl)-2-azetidinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C16H21ClN2O;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
at -78 - 20 ℃;
With
oxalic acid;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.0166667h;
Further stages.;
DOI:10.1021/jo0162437
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 76 percent / sodium borohydride / methanol / 0 °C
2.1: 67 percent / AlMe3 / CH2Cl2; heptane / 0 - 20 °C
3.1: 84 percent / triphenylphosphine; carbon tetrachloride; triethylamine / acetonitrile / 0 - 20 °C
4.1: H2 / Pd/C / methanol
5.1: 160 mg / TsN3; trimethylsilyl azide; diisopropylethylamine / acetonitrile / 108 h / 0 - 20 °C
6.1: 76 percent / CsF / dimethylformamide
7.1: H2 / 10percent Pd/C / tetrahydrofuran / 0.33 h
8.1: tert-butyl hypochlorite / tetrahydrofuran / 0.08 h / -78 °C
9.1: DBU / tetrahydrofuran / -78 - 20 °C
9.2: 9 mg / oxalic acid / tetrahydrofuran; H2O / 0.02 h / 20 °C
With
tetrachloromethane; sodium tetrahydroborate; 4-toluenesulfonyl azide; tert-butylhypochlorite; trimethylsilylazide; hydrogen; trimethylaluminum; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; cesium fluoride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo0162437
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 67 percent / AlMe3 / CH2Cl2; heptane / 0 - 20 °C
2.1: 84 percent / triphenylphosphine; carbon tetrachloride; triethylamine / acetonitrile / 0 - 20 °C
3.1: H2 / Pd/C / methanol
4.1: 160 mg / TsN3; trimethylsilyl azide; diisopropylethylamine / acetonitrile / 108 h / 0 - 20 °C
5.1: 76 percent / CsF / dimethylformamide
6.1: H2 / 10percent Pd/C / tetrahydrofuran / 0.33 h
7.1: tert-butyl hypochlorite / tetrahydrofuran / 0.08 h / -78 °C
8.1: DBU / tetrahydrofuran / -78 - 20 °C
8.2: 9 mg / oxalic acid / tetrahydrofuran; H2O / 0.02 h / 20 °C
With
tetrachloromethane; 4-toluenesulfonyl azide; tert-butylhypochlorite; trimethylsilylazide; hydrogen; trimethylaluminum; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; cesium fluoride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo0162437
