2,6-dichloro-3,5-dimethoxybenzyl alcohol

Base Information

• Chemical Name: 2,6-dichloro-3,5-dimethoxybenzyl alcohol
• CAS No.: 75177-60-5
• Molecular Formula: C₉H₁₀Cl₂O₃
• Molecular Weight: 237.083
• Mol file: 75177-60-5.mol

Synonyms:2,6-dichloro-3,5-dimethoxybenzyl alcohol

Chemical Property of 2,6-dichloro-3,5-dimethoxybenzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dichloro-3,5-dimethoxybenzyl alcohol

There total 8 articles about 2,6-dichloro-3,5-dimethoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,5-dimethoxybenzyl alcohol (705-76-0) → 2,6-dichloro-3,5-dimethoxybenzyl alcohol (75177-60-5)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(99)01314-3

Reference yield:

2,6-dichloro-3,5-dimethoxy benzaldehyde (287175-08-0) → 2,6-dichloro-3,5-dimethoxybenzyl alcohol (75177-60-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.04.014

Reference yield:

C10H10Cl2O4 → 2,6-dichloro-3,5-dimethoxybenzyl alcohol (75177-60-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;

upstream raw materials:

3,5-dimethoxybenzyl alcohol

methyl 3,5-dimethoxybenzoate

3,5-dimethoxybenzoic acid

ethyl 3,5-dimethoxybenzoate

Downstream raw materials:

2-chloro-5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]pyrimidine

3-allyloxymethyl-2,4-dichloro-1,5-dimethoxy-benzene

Refernces

• 1、 -. "FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF". Paragraph 0156-0158. . Retrieved 2019/10/10.
• 2、 Braese, Stefan. "Intramolecular transition-metal catalyzed cyclizations of electron rich chloroarenes". . p. 6757 - 6759. Retrieved 2007/10/03.