(2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-(tert-butyldimethylsilanyloxy)-2-vinylhex-5-en-1-one

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Chemical Name:(2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-(tert-butyldimethylsilanyloxy)-2-vinylhex-5-en-1-one
CAS No.:350987-71-2
Molecular Formula:C₂₄H₃₅NO₃SSi
Molecular Weight:445.698
Hs Code.:

Synonyms:(2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-(tert-butyldimethylsilanyloxy)-2-vinylhex-5-en-1-one

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Chemical Property of (2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-(tert-butyldimethylsilanyloxy)-2-vinylhex-5-en-1-one

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Technology Process of (2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-(tert-butyldimethylsilanyloxy)-2-vinylhex-5-en-1-one

There total 3 articles about (2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-(tert-butyldimethylsilanyloxy)-2-vinylhex-5-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 350987-67-6
(2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-hydroxy-2-vinylhex-5-en-1-one

: 350987-71-2
(2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-(tert-butyldimethylsilanyloxy)-2-vinylhex-5-en-1-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jo015568k

Reference yield:

: (R)-4-benzyl-2-oxazolidinethione

: 350987-71-2
(2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-(tert-butyldimethylsilanyloxy)-2-vinylhex-5-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

2.1: titanium tetrachloride; (-)-sparteine / CH₂Cl₂ / 2 h / -78 °C

2.2: 75 percent / CH₂Cl₂ / -78 - 0 °C

3.1: 70 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / 0 °C

With 2,6-dimethylpyridine; titanium tetrachloride; triethylamine; (-)-sparteine; In dichloromethane; 2.2: Evans aldol reaction;
DOI:10.1021/jo015568k

Reference yield:

: 350987-65-4
1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]but-2-en-1-one

: 350987-71-2
(2R,3S)-1-[(4R)-4-benzyl-2-thioxooxazolidin-3-yl]-3-(tert-butyldimethylsilanyloxy)-2-vinylhex-5-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium tetrachloride; (-)-sparteine / CH₂Cl₂ / 2 h / -78 °C

1.2: 75 percent / CH₂Cl₂ / -78 - 0 °C

2.1: 70 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / 0 °C

With 2,6-dimethylpyridine; titanium tetrachloride; (-)-sparteine; In dichloromethane; 1.2: Evans aldol reaction;
DOI:10.1021/jo015568k