(R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-4-oxo-butyric acid ethyl ester

Base Information

Chemical Name:(R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-4-oxo-butyric acid ethyl ester
CAS No.:212776-45-9
Molecular Formula:C₁₇H₂₁NO₇
Molecular Weight:351.356
Hs Code.:

Synonyms:(R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-4-oxo-butyric acid ethyl ester

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Chemical Property of (R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-4-oxo-butyric acid ethyl ester

Chemical Property:

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Technology Process of (R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-4-oxo-butyric acid ethyl ester

There total 8 articles about (R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-4-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 212776-44-8
(R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-pent-4-enoic acid ethyl ester

: 212776-45-9
(R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-4-oxo-butyric acid ethyl ester

Guidance literature:: With ozone; In methanol; diethyl ether; Ambient temperature;
DOI:10.1016/S0040-4039(98)01123-X

Reference yield:

: 6829-40-9
aminomalonic acid diethyl ester

: 212776-45-9
(R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-4-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / NaHCO₃ / H₂O; diethyl ether / Ambient temperature

2: NaH / H₂O; diethyl ether

3: porcine liver esterase, 1/15M phosphate buffer (pH_7.0) / H₂O; acetonitrile / 240 h / Ambient temperature

4: cyanuric fluoride, pyridine / CH₂Cl₂ / 0 °C

5: NaBH₄ / methanol / 0 °C

6: 88 percent / pyridine / CH₂Cl₂ / 0 °C

7: 100 percent / O₃ / diethyl ether; methanol / Ambient temperature

With pyridine; porcine liver esterase; sodium tetrahydroborate; trifluoro-[1,3,5]triazine; phosphate buffer; sodium hydride; sodium hydrogencarbonate; ozone; In methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(98)01123-X

Reference yield:

: 3005-66-1
diethyl 2-benzyloxycarbonylaminomalonate

: 212776-45-9
(R)-2-Acetoxymethyl-2-benzyloxycarbonylamino-4-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / H₂O; diethyl ether

2: porcine liver esterase, 1/15M phosphate buffer (pH_7.0) / H₂O; acetonitrile / 240 h / Ambient temperature

3: cyanuric fluoride, pyridine / CH₂Cl₂ / 0 °C

4: NaBH₄ / methanol / 0 °C

5: 88 percent / pyridine / CH₂Cl₂ / 0 °C

6: 100 percent / O₃ / diethyl ether; methanol / Ambient temperature

With pyridine; porcine liver esterase; sodium tetrahydroborate; trifluoro-[1,3,5]triazine; phosphate buffer; sodium hydride; ozone; In methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(98)01123-X