tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate

Base Information

• Chemical Name: tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate
• CAS No.: 960215-52-5
• Molecular Formula: C₂₈H₃₄ClN₃O₅
• Molecular Weight: 528.048
• Mol file: 960215-52-5.mol

Synonyms:tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate

Chemical Property of tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate

There total 2 articles about tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-amino-4-[(tert-butyloxycarbonyl)amino]butane (68076-36-8) + [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate (960215-52-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate (960215-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201500439

Reference yield: 98.0%

tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate (960215-52-5) → N-(4-aminobutyl)-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide hydrochloride (960215-53-6)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

di-tert-butyl dicarbonate

Downstream raw materials:

N-(4-aminobutyl)-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide hydrochloride

N-(4-aminobutyl)-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide