3-{(2S,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazin-2-yl}-propan-1-ol

Base Information

• Chemical Name: 3-{(2S,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazin-2-yl}-propan-1-ol
• CAS No.: 634893-06-4
• Molecular Formula: C₂₉H₄₀N₂O₄
• Molecular Weight: 480.648

Synonyms:3-{(2S,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazin-2-yl}-propan-1-ol

Chemical Property of 3-{(2S,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazin-2-yl}-propan-1-ol

Chemical Property:

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Technology Process of 3-{(2S,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazin-2-yl}-propan-1-ol

There total 3 articles about 3-{(2S,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazin-2-yl}-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-iodopropan-3-ol (627-32-7) + (2R,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine → 3-{(2S,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazin-2-yl}-propan-1-ol (634893-06-4)

Guidance literature:

(2R,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃;

1-iodopropan-3-ol; In tetrahydrofuran; hexane; at -78 - 0 ℃;

DOI:10.1055/s-2003-40883

Reference yield:

(2R)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine (110117-71-0) → 3-{(2S,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazin-2-yl}-propan-1-ol (634893-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / -78 - 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

2.2: tetrahydrofuran; hexane / -78 - 0 °C

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1055/s-2003-40883

Reference yield:

2-<4-(Benzyloxy)phenyl>ethyl iodide (163930-30-1) → 3-{(2S,5R)-2-[2-(4-Benzyloxy-phenyl)-ethyl]-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazin-2-yl}-propan-1-ol (634893-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / -78 - 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

2.2: tetrahydrofuran; hexane / -78 - 0 °C

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1055/s-2003-40883

upstream raw materials:

1-iodopropan-3-ol

(2R)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine

2-<4-(Benzyloxy)phenyl>ethyl iodide

Downstream raw materials:

{1-[2-(4-heptyloxy-phenyl)-ethyl]-4-hydroxy-1-hydroxymethyl-butyl}-carbamic acid tert-butyl ester

{1-[2-(4-benzyloxy-phenyl)-ethyl]-4-hydroxy-1-hydroxymethyl-butyl}-carbamic acid tert-butyl ester

{4-hydroxy-1-hydroxymethyl-1-[2-(4-hydroxy-phenyl)-ethyl]-butyl}-carbamic acid tert-butyl ester

(S)-2-Amino-2-[2-(4-benzyloxy-phenyl)-ethyl]-5-hydroxy-pentanoic acid ethyl ester

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