(E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoic acid

Base Information

• Chemical Name: (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoic acid
• CAS No.: 1308279-88-0
• Molecular Formula: C₂₃H₂₄N₂O₃
• Molecular Weight: 376.455
• Mol file: 1308279-88-0.mol

Synonyms:(E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoic acid

Chemical Property of (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoic acid

There total 3 articles about (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoate (1308279-82-4) → (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoic acid (1308279-88-0)

Guidance literature:

ethyl (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoate; With water; sodium hydroxide; In methanol; at 82 ℃; for 0.833333h; Inert atmosphere;

With hydrogenchloride; In methanol; water; at 20 ℃; Inert atmosphere;

Reference yield:

(E)-3-(6-chloropyridazin-3-yl)-acrylic acid ethyl ester (1308279-70-0) → (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoic acid (1308279-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 90 °C

2.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

2.2: pH 7 - 8 / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 0.83 h / 82 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With water; boron tribromide; sodium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

ethyl (E)-3-{6-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-pyridazinyl}-2-propenoate (1308279-76-6) → (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoic acid (1308279-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

1.2: pH 7 - 8 / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 0.83 h / 82 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With water; boron tribromide; sodium hydroxide; In methanol; dichloromethane;

upstream raw materials:

ethyl (E)-3-{6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-pyridazinyl}-2-propenoate

(E)-3-(6-chloropyridazin-3-yl)-acrylic acid ethyl ester

ethyl (E)-3-{6-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-pyridazinyl}-2-propenoate