(S_s,2S,3S)-ethyl 2-(tert-butoxycarbonyloxy)-4-chloro-3-(p-toluenesulfinylamino)butanoate

Base Information

• Chemical Name: (S_s,2S,3S)-ethyl 2-(tert-butoxycarbonyloxy)-4-chloro-3-(p-toluenesulfinylamino)butanoate
• CAS No.: 1609490-95-0
• Molecular Formula: C₁₈H₂₆ClNO₆S
• Molecular Weight: 419.927

Synonyms:(S_s,2S,3S)-ethyl 2-(tert-butoxycarbonyloxy)-4-chloro-3-(p-toluenesulfinylamino)butanoate

Chemical Property of (S_s,2S,3S)-ethyl 2-(tert-butoxycarbonyloxy)-4-chloro-3-(p-toluenesulfinylamino)butanoate

Chemical Property:

Purity/Quality:

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Technology Process of (S_s,2S,3S)-ethyl 2-(tert-butoxycarbonyloxy)-4-chloro-3-(p-toluenesulfinylamino)butanoate

There total 2 articles about (S_s,2S,3S)-ethyl 2-(tert-butoxycarbonyloxy)-4-chloro-3-(p-toluenesulfinylamino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

ethyl 2-(tert-butoxycarbonyloxy)acetate (1609490-80-3) + C9H10ClNOS → (Ss,2S,3S)-ethyl 2-(tert-butoxycarbonyloxy)-4-chloro-3-(p-toluenesulfinylamino)butanoate (1609490-95-0)

Guidance literature:

ethyl 2-(tert-butoxycarbonyloxy)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

C₉H₁₀ClNOS; In tetrahydrofuran; at -78 ℃; for 4h; diastereoselective reaction; Inert atmosphere;

DOI:10.1039/c4ob00243a

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (Ss,2S,3S)-ethyl 2-(tert-butoxycarbonyloxy)-4-chloro-3-(p-toluenesulfinylamino)butanoate (1609490-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap / acetonitrile / 18 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 °C / Inert atmosphere

With dmap; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile; 2.2: |Mannich Aminomethylation;

DOI:10.1039/c4ob00243a

upstream raw materials:

ethyl 2-(tert-butoxycarbonyloxy)acetate

di-tert-butyl dicarbonate

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