deoxyguanylyl-(3'-5')-guanosine

Base Information

• Chemical Name: deoxyguanylyl-(3'-5')-guanosine
• CAS No.: 15180-30-0
• Molecular Formula: C₂₀H₂₅N₁₀O₁₀P
• Molecular Weight: 596.453
• Mol file: 15180-30-0.mol

Synonyms:11:PN: US20060052323 PAGE: 23 claimed sequence; 1: PN: WO03093504 PAGE: 136claimed DNA; 2'-Deoxyguanylyl(3'®5')-2'-deoxyguanosine

Chemical Property of deoxyguanylyl-(3'-5')-guanosine

Chemical Property:

• Boiling Point: 1117.3°Cat760mmHg
• PKA: 1.37±0.50(Predicted)
• Flash Point: 629.5°C
• PSA: 303.67000
• Density: 2.32g/cm³
• LogP: -0.99000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of deoxyguanylyl-(3'-5')-guanosine

There total 7 articles about deoxyguanylyl-(3'-5')-guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Dithiophosphoric acid O-[(2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl] ester O'-[(2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl] ester → 2'-Desoxyguanylyl-(3'-5')-2'-desoxyguanosin (15180-30-0)

Guidance literature:

With ethyloxirane; In ethanol; at 50 ℃; for 3h;

DOI:10.1021/jo00126a060

Reference yield:

9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one → 2'-Desoxyguanylyl-(3'-5')-2'-desoxyguanosin (15180-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) tetrazole, 2.) S₈ / 1.) r.t., 1 h, 2.) r.t., overnight

3: butylene 1,2-oxide / aq. ethanol / 3 h / 50 °C

With ethyloxirane; 1H-tetrazole; sulfur; In ethanol;

DOI:10.1021/jo00126a060

Reference yield:

9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ5-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one (172033-39-5) → 2'-Desoxyguanylyl-(3'-5')-2'-desoxyguanosin (15180-30-0)

Guidance literature:

Multi-step reaction with 2 steps

2: butylene 1,2-oxide / aq. ethanol / 3 h / 50 °C

With ethyloxirane; In ethanol;

DOI:10.1021/jo00126a060

upstream raw materials:

GGAATTCC

9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one