Technology Process of 7-(2',3',4,5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine
There total 14 articles about 7-(2',3',4,5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2'-bromo-2,3,4',5'-tetramethoxy-1,1'-biphenyl;
With
tert.-butyl lithium;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
With
zinc dibromide;
In
tetrahydrofuran;
at -78 ℃;
for 0.166667h;
1,2,3,5,8,8a-hexahydroindolizin-7-yl trifluoromethanesulfonate;
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
at 20 - 25 ℃;
for 1h;
DOI:10.1021/ol1023954
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 0 - 20 °C
2.1: formic acid; sodium iodide / 6 h / 20 °C / Inert atmosphere
3.1: methanol; potassium carbonate / 1.25 h
4.1: L-Selectride / tetrahydrofuran / 3.25 h / -78 - 0 °C / Inert atmosphere
4.2: 3 h / -78 - 0 °C / Inert atmosphere
5.1: tert.-butyl lithium / tetrahydrofuran / 2 h / -78 °C
5.2: 0.17 h / -78 °C
5.3: 1 h / 20 - 25 °C
With
methanol; formic acid; tert.-butyl lithium; L-Selectride; potassium carbonate; sodium iodide;
In
tetrahydrofuran;
5.1: Negishi coupling reaction / 5.2: Negishi coupling reaction / 5.3: Negishi coupling reaction;
DOI:10.1021/ol1023954
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: L-Selectride / tetrahydrofuran / 3.25 h / -78 - 0 °C / Inert atmosphere
1.2: 3 h / -78 - 0 °C / Inert atmosphere
2.1: tert.-butyl lithium / tetrahydrofuran / 2 h / -78 °C
2.2: 0.17 h / -78 °C
2.3: 1 h / 20 - 25 °C
With
tert.-butyl lithium; L-Selectride;
In
tetrahydrofuran;
2.1: Negishi coupling reaction / 2.2: Negishi coupling reaction / 2.3: Negishi coupling reaction;
DOI:10.1021/ol1023954
