[7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinolin-1-yl]-phenyl-methanone

Base Information

Chemical Name:[7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinolin-1-yl]-phenyl-methanone
CAS No.:352016-39-8
Molecular Formula:C₂₅H₂₃NO₄
Molecular Weight:401.462
Hs Code.:

Synonyms:[7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinolin-1-yl]-phenyl-methanone

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Chemical Property of [7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinolin-1-yl]-phenyl-methanone

Chemical Property:

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Technology Process of [7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinolin-1-yl]-phenyl-methanone

There total 7 articles about [7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinolin-1-yl]-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 478855-25-3
1-benzyl-7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinoline

: 352016-39-8
[7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinolin-1-yl]-phenyl-methanone

Guidance literature:: With air; palladium on activated charcoal; In acetonitrile; at 20 ℃;
DOI:10.1021/jm020831a

Reference yield:

: 621-59-0
isovanillin

: 352016-39-8
[7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinolin-1-yl]-phenyl-methanone

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / K₂CO₃ / ethanol / 5 h / Heating

2: 88 percent / NH₄OAc; AcOH / 4 h / Heating

3: 63 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

4: 68 percent / 5percent aq. NaOH / CH₂Cl₂ / 2 h / 20 °C

5: 97 percent / conc. HCl / ethanol / 4 h / Heating

6: K₂CO₃ / acetone / 10 h / Heating

7: POCl₃ / CH₂Cl₂ / 3 h / Heating

8: 90 percent / air / Pd/C / acetonitrile / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; air; ammonium acetate; potassium carbonate; acetic acid; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone; acetonitrile; 4: Schotten-Baumann reaction / 7: Bischler-Napieralski cyclodehydration;
DOI:10.1021/jm020831a

Reference yield:

: 63909-29-5,55507-05-6
3-benzyloxy-4-methoxy-β-nitrostyrene

: 352016-39-8
[7-methoxy-6-(4-methoxy-benzyloxy)-3,4-dihydro-isoquinolin-1-yl]-phenyl-methanone

Guidance literature:: Multi-step reaction with 6 steps

1: 63 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

2: 68 percent / 5percent aq. NaOH / CH₂Cl₂ / 2 h / 20 °C

3: 97 percent / conc. HCl / ethanol / 4 h / Heating

4: K₂CO₃ / acetone / 10 h / Heating

5: POCl₃ / CH₂Cl₂ / 3 h / Heating

6: 90 percent / air / Pd/C / acetonitrile / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; air; potassium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone; acetonitrile; 2: Schotten-Baumann reaction / 5: Bischler-Napieralski cyclodehydration;
DOI:10.1021/jm020831a