R/S-N-2-chlorophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran-4-yl)urea

Base Information

Chemical Name:R/S-N-2-chlorophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran-4-yl)urea
CAS No.:1392810-22-8
Molecular Formula:C₂₁H₂₄ClN₃O₄
Molecular Weight:417.892
Hs Code.:

Synonyms:R/S-N-2-chlorophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran-4-yl)urea

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Chemical Property of R/S-N-2-chlorophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran-4-yl)urea

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Technology Process of R/S-N-2-chlorophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran-4-yl)urea

There total 8 articles about R/S-N-2-chlorophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1392810-25-1
R/S-4-amino-6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran

: 3320-83-0
o-chlorophenyl isocyanate

: 1392810-22-8
R/S-N-2-chlorophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran-4-yl)urea

Guidance literature:: In dichloromethane; for 0.5h;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1392810-22-8
R/S-N-2-chlorophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran-4-yl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydroxide / water / 5 h / Reflux

2: sulfuric acid / ethyl acetate / 5 h / 50 °C

3: ammonium chloride; iron / ethanol; water / 0.25 h / 80 °C

4: potassium carbonate / water / 15 h / 40 °C

5: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 8 h / 20 °C

6: hydrogen / Raney nickel / ethanol / 4 h / 7500.75 Torr

7: dichloromethane / 0.5 h

With sulfuric acid; hydroxylamine hydrochloride; hydrogen; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; potassium hydroxide; Raney nickel; In ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 103441-69-6
6-aminochroman-4-one

: 1392810-22-8
R/S-N-2-chlorophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2H-1-benzopyran-4-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / water / 15 h / 40 °C

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 8 h / 20 °C

3: hydrogen / Raney nickel / ethanol / 4 h / 7500.75 Torr

4: dichloromethane / 0.5 h

With hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; potassium carbonate; Raney nickel; In ethanol; dichloromethane; water;