(4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one

Base Information

Chemical Name:(4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one
CAS No.:213838-20-1
Molecular Formula:C₂₀H₂₇NO₃S
Molecular Weight:361.505
Hs Code.:

Synonyms:(4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one

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Chemical Property of (4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one

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Technology Process of (4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one

There total 1 articles about (4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: (1S,2R,6R)-2-Methyl-6-{1-[1-(toluene-4-sulfonyl)-meth-(Z)-ylidene]-butylamino}-cyclohexanecarboxylic acid methyl ester

: 213838-20-1
(4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.333333h;
DOI:10.1021/jo980647q

Reference yield:

: 213838-20-1
(4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one

: 213838-28-9
(2S,4aS,5R,8aR)-5-Methyl-2-propyl-octahydro-quinoline-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 192 mg / CH₂Cl₂ / 18 h / Heating

2: H₂ / PtO₂ / methanol / 144 h / 76000 Torr

3: 123 mg / aq. K₂CO₃ / CHCl₃ / 3 h / Heating

4: 52 mg / Na/Hg, Na₂HPO₄ / methanol; tetrahydrofuran / 5 h / Ambient temperature

With disodium hydrogenphosphate; sodium amalgam; hydrogen; potassium carbonate; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1021/jo980647q

Reference yield:

: 213838-20-1
(4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one

: (2S,4aS,5R,8aR)-5-Methyl-2-propyl-3-(toluene-4-sulfonyl)-decahydro-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 192 mg / CH₂Cl₂ / 18 h / Heating

2: H₂ / PtO₂ / methanol / 144 h / 76000 Torr

With hydrogen; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1021/jo980647q