(E,E)-6(R),7(R)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene

Base Information

• Chemical Name: (E,E)-6(R),7(R)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene
• CAS No.: 314249-74-6
• Molecular Formula: C₂₈H₃₆N₂
• Molecular Weight: 400.607
• Mol file: 314249-74-6.mol

Synonyms:(E,E)-6(R),7(R)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene

Chemical Property of (E,E)-6(R),7(R)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E,E)-6(R),7(R)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene

There total 3 articles about (E,E)-6(R),7(R)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1,4-Pentadiene (591-93-5) + (S,S)-N.N'-ethanediylidene-bis(α-methylbenzenemethylamine) → (E,E)-6(S),7(S)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene + (E,E)-6(R),7(R)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene (314249-74-6)

Guidance literature:

1,4-Pentadiene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1h;

(S,S)-N.N'-ethanediylidene-bis(α-methylbenzenemethylamine); In tetrahydrofuran; at -78 ℃; for 2.5h;

DOI:10.1016/S0040-4020(00)00782-1

Reference yield: 59.0%

(4R,5R)-N,N'-bis[(1S)-1-phenylethyl]-3,6-divinyl-1,7-octadiene-4,5-diamine (280142-38-3) → (E,E)-6(R),7(R)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene (314249-74-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; -78 degC, 1 h then allowed to come to 20 degC over 2 h;

DOI:10.1002/1099-0690(200108)2001:15<2917::AID-EJOC2917>3.0.CO;2-X

Reference yield: 28.0%

phenyllithium (591-51-5) + (4R,5R)-N,N'-bis[(1S)-1-phenylethyl]-3,6-divinyl-1,7-octadiene-4,5-diamine (280142-38-3) → (E,E)-6(R),7(R)-di-[(S)-1-phenylethylamino]-1,3,9,11-dodecatetraene (314249-74-6) + (1R,2R,4E)-1-phenyl-N,N'-bis[(1S)-1-phenylethyl]-4,6-heptadiene-1,2-diamine

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1002/1099-0690(200108)2001:15<2917::AID-EJOC2917>3.0.CO;2-X

upstream raw materials:

1,4-Pentadiene

phenyllithium

(4R,5R)-N,N'-bis[(1S)-1-phenylethyl]-3,6-divinyl-1,7-octadiene-4,5-diamine