(2R,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(3-chloro-4-cyano-2-methyl-phenylamino)methyl]pyrrolidine, trifluoroacetic acid salt

Base Information

• Chemical Name: (2R,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(3-chloro-4-cyano-2-methyl-phenylamino)methyl]pyrrolidine, trifluoroacetic acid salt
• CAS No.: 863204-78-8
• Molecular Formula: C₂HF₃O₂*C₁₉H₃₀ClN₃OSi
• Molecular Weight: 494.029
• Mol file: 863204-78-8.mol

Synonyms:(2R,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(3-chloro-4-cyano-2-methyl-phenylamino)methyl]pyrrolidine, trifluoroacetic acid salt

Chemical Property of (2R,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(3-chloro-4-cyano-2-methyl-phenylamino)methyl]pyrrolidine, trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(3-chloro-4-cyano-2-methyl-phenylamino)methyl]pyrrolidine, trifluoroacetic acid salt

There total 1 articles about (2R,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(3-chloro-4-cyano-2-methyl-phenylamino)methyl]pyrrolidine, trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-2-chloro-3-methyl-benzonitrile (573768-09-9) + tert-butyl (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-formylpyrrolidine-1-carboxylate (757247-71-5) + trifluoroacetic acid (76-05-1) → (2R,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(3-chloro-4-cyano-2-methyl-phenylamino)methyl]pyrrolidine, trifluoroacetic acid salt (863204-78-8)

Guidance literature:

4-amino-2-chloro-3-methyl-benzonitrile; tert-butyl (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-formylpyrrolidine-1-carboxylate; With sodium tris(acetoxy)borohydride; In DMF (N,N-dimethyl-formamide); dichloromethane; acetic acid; at 20 ℃; for 24h;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

(2R,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(3-chloro-4-cyano-2-methyl-phenylamino)methyl]pyrrolidine, trifluoroacetic acid salt (863204-78-8) → (2R,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(3-chloro-4-cyano-2-methyl-phenylamino)methyl]pyrrolidine-1-sulfonic acid, N,N,N-diisopropyl ethylamine salt

Guidance literature:

With chlorosulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

4-amino-2-chloro-3-methyl-benzonitrile

tert-butyl (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-formylpyrrolidine-1-carboxylate

trifluoroacetic acid

Refernces