Technology Process of (S)-phenyl(2,5,5-trimethylcyclopent-2-enyl)methanone
There total 3 articles about (S)-phenyl(2,5,5-trimethylcyclopent-2-enyl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(R)-DTBM-SEGPHOS(AuCl)2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate;
In
dichloromethane;
at -50 ℃;
for 16h;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1021/ja210388g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: (R)-DTBM-SEGPHOS(AuCl)2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 16 h / -50 °C
With
(R)-DTBM-SEGPHOS(AuCl)2; potassium hexamethylsilazane; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja210388g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / benzene / Reflux; Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 4 h
4.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
5.1: (R)-DTBM-SEGPHOS(AuCl)2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 16 h / -50 °C
With
hydrogenchloride; (R)-DTBM-SEGPHOS(AuCl)2; potassium hexamethylsilazane; toluene-4-sulfonic acid; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; benzene;
DOI:10.1021/ja210388g
