2-{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}-N-(1-methylethyl)acetamide

Base Information

• Chemical Name: 2-{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}-N-(1-methylethyl)acetamide
• CAS No.: 1161086-94-7
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368

Synonyms:2-{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}-N-(1-methylethyl)acetamide

Chemical Property of 2-{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}-N-(1-methylethyl)acetamide

Chemical Property:

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Technology Process of 2-{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}-N-(1-methylethyl)acetamide

There total 1 articles about 2-{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}-N-(1-methylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}acetic acid (1161086-91-4) + isopropylamine (75-31-0) → 2-{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}-N-(1-methylethyl)acetamide (1161086-94-7)

Guidance literature:

{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}acetic acid; With Carbonyldiimidazole; In acetonitrile; for 2h; Heating / reflux;

isopropylamine; In acetonitrile; at 20 ℃;

Reference yield: 16.0%

2-{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}-N-(1-methylethyl)acetamide (1161086-94-7) + 2,4-difluoro-5-({[(3-fluorophenyl)(4-piperidinyl)amino]carbonyl}amino)benzamide hydrochloride → 2,4-difluoro-5-[({(3-fluorophenyl)[1-({2-methyl-6-[(4-{2-[(1-methylethyl)amino]-2-oxoethyl}phenyl)oxy]-3-pyridinyl}methyl)-4-piperidinyl]amino}carbonyl)amino]benzamide (1161086-30-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

2-{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}-N-(1-methylethyl)acetamide (1161086-94-7) + C21H22F2N4O2*ClH → C39H42F2N6O4 (1344151-85-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2011.08.096

upstream raw materials:

{4-[(5-formyl-6-methyl-2-pyridinyl)oxy]phenyl}acetic acid

isopropylamine

Downstream raw materials:

2,4-difluoro-5-[({(3-fluorophenyl)[1-({2-methyl-6-[(4-{2-[(1-methylethyl)amino]-2-oxoethyl}phenyl)oxy]-3-pyridinyl}methyl)-4-piperidinyl]amino}carbonyl)amino]benzamide

C₃₉H₄₂F₂N₆O₄

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