N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide

Base Information

Chemical Name:N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide
CAS No.:1292310-43-0
Molecular Formula:C₂₆H₂₈N₆O₂
Molecular Weight:456.547
Hs Code.:

Synonyms:N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide

Suppliers and Price of N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide

There total 3 articles about N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1292312-68-5
2-amino-5-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)benzonitrile

: 108-12-3
isopentanoyl chloride

: 1292310-43-0
N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide

Guidance literature:: With pyridine; at 85 ℃; for 3h; Sealed with tube;

Reference yield:

: 39263-32-6
2-amino-5-bromobenzonitrile

: 1292310-43-0
N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 80 °C

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 5 h / 80 °C

3: 1,4-dioxane; ethanol / 72 h / 100 °C

4: pyridine / 3 h / 85 °C / Sealed with tube

With pyridine; potassium acetate; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; water; acetonitrile;

Reference yield:

: 934426-22-9
2‐amino‐5‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)benzonitrile

: 1292310-43-0
N-[2-cyano-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)phenyl]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 5 h / 80 °C

2: 1,4-dioxane; ethanol / 72 h / 100 °C

3: pyridine / 3 h / 85 °C / Sealed with tube

With pyridine; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; acetonitrile;