(R,S)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine

Base Information

Chemical Name:(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine
CAS No.:172755-30-5
Molecular Formula:C₄₇H₅₈N₄O₆S₂
Molecular Weight:839.133
Hs Code.:

(R*,S*)-N-<<2-<N-<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine

Synonyms:(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine

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Chemical Property of (R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine

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Technology Process of (R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine

There total 7 articles about (R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 166168-92-9
(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

: 172755-30-5
(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; for 24h;
DOI:10.1021/jm950642a

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 172755-30-5
(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / Bop-Cl, N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 0 °C

2: 99 percent / 4 N HCl / CH₂Cl₂; dioxane; various solvent(s) / 1 h

3: 67 percent / 3 Angstroem molecular sieves, glacial acetic acid, NaBH₃CN / methanol / 16 h / Ambient temperature

4: 99 percent / methanolic LiOH / tetrahydrofuran / 24 h

With hydrogenchloride; lithium hydroxide; 3 A molecular sieve; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm950642a

Reference yield:

: 115962-35-1,144069-68-1,78879-20-6
(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid

: 172755-30-5
(R*,S*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NMP, diisopropylethylamine, hydroxybenzotriazole, diisopropylethylamine, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 4 deg C, 5 min, 2.) CH₂Cl₂, RT, 16 h

2: 99 percent / 4 N HCl / CH₂Cl₂; various solvent(s); dioxane / 1 h

3: 97 percent / Bop-Cl, N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 0 °C

4: 99 percent / 4 N HCl / CH₂Cl₂; dioxane; various solvent(s) / 1 h

5: 67 percent / 3 Angstroem molecular sieves, glacial acetic acid, NaBH₃CN / methanol / 16 h / Ambient temperature

6: 99 percent / methanolic LiOH / tetrahydrofuran / 24 h

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; lithium hydroxide; 3 A molecular sieve; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm950642a