(S)-7-(Dimethoxy-phosphoryl)-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-heptanoic acid tert-butyl ester

Base Information

• Chemical Name: (S)-7-(Dimethoxy-phosphoryl)-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-heptanoic acid tert-butyl ester
• CAS No.: 215182-83-5
• Molecular Formula: C₃₂H₃₈NO₆P
• Molecular Weight: 563.631
• Mol file: 215182-83-5.mol

Synonyms:(S)-7-(Dimethoxy-phosphoryl)-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-heptanoic acid tert-butyl ester

Chemical Property of (S)-7-(Dimethoxy-phosphoryl)-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-heptanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-7-(Dimethoxy-phosphoryl)-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-heptanoic acid tert-butyl ester

There total 1 articles about (S)-7-(Dimethoxy-phosphoryl)-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-heptanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1-tert-Butyl 6-methyl (S)-2-[N-(9-phenylfluoren-9-yl)amino]hexandioate (147698-06-4) + dimethyl methane phosphonate (756-79-6) → (1S,3R/S)-1-[N-(9-Phenylfluoren-9-yl)amino]-2-oxo-3-(methoxycarbonyl)cyclopentane (215182-84-6) + (S)-7-(Dimethoxy-phosphoryl)-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-heptanoic acid tert-butyl ester (215182-83-5)

Guidance literature:

With n-butyllithium; In diethyl ether; hexane; at -78 ℃; Product distribution; other solvent;

DOI:10.1021/jo9814602

Reference yield: 78.0%

tert-butyl (2S)-2-[(9-phenyl-9-fluorenyl)amino]-4-oxobutanoate (215182-76-6) + (S)-7-(Dimethoxy-phosphoryl)-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-heptanoic acid tert-butyl ester (215182-83-5) → (E)-(2S,10S)-6-Oxo-2,10-bis-(9-phenyl-9H-fluoren-9-ylamino)-undec-4-enedioic acid di-tert-butyl ester

Guidance literature:

With potassium carbonate; In acetonitrile; at 25 ℃; for 96h;

DOI:10.1021/jo9814602

Reference yield: 60.0%

(4S)-2-oxo-3-(9-phenylfluoren-9-yl)oxazolidine-4-carboxaldehyde (122213-54-1) + (S)-7-(Dimethoxy-phosphoryl)-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-heptanoic acid tert-butyl ester (215182-83-5) → 6-oxo-8-[2-oxo-3-(9-phenyl-9H-fluoren-9-yl)-oxazolidin-4-yl]-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-7-enoic acid tert-butyl ester

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 48h;

DOI:10.1021/jo991766o

upstream raw materials:

1-tert-Butyl 6-methyl (S)-2-[N-(9-phenylfluoren-9-yl)amino]hexandioate

dimethyl methane phosphonate