2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)-N-((3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methyl)propanamide

Base Information

Chemical Name:2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)-N-((3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methyl)propanamide
CAS No.:1428764-37-7
Molecular Formula:C₂₆H₂₆F₄N₂O₃S
Molecular Weight:522.564
Hs Code.:

Synonyms:2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)-N-((3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methyl)propanamide

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Chemical Property of 2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)-N-((3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methyl)propanamide

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Technology Process of 2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)-N-((3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methyl)propanamide

There total 4 articles about 2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)-N-((3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1428745-42-9
2-(3-fluoro-4-(methylsulfonamido-methyl)phenyl)propanoic acid

: 1428765-61-0
(3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methanamine

: 1428764-37-7
2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)-N-((3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methyl)propanamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In acetonitrile; at 20 ℃; for 15h;

Reference yield:

: 112734-22-2
4-bromo-2-fluorobenzylamine

: 1428764-37-7
2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)-N-((3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 1 h / 0 °C

2.1: manganese; bis(bipyridine)nickel(II) bromide; trifluoroacetic acid / N,N-dimethyl-formamide / 36 h / 20 - 65 °C

3.1: lithium hydroxide; water / tetrahydrofuran / 12 h / Reflux

3.2: pH 2

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 20 °C

With pyridine; manganese; bis(bipyridine)nickel(II) bromide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1402586-73-5
ethyl 2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanoate

: 1428764-37-7
2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)-N-((3′-methyl-5-(trifluoromethyl)biphenyl-2-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 12 h / Reflux

1.2: pH 2

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; acetonitrile;