diethyl N-ethyl-4-chloro-3-(4-phenyl-2-thiazolyl)anilinomethylenemalonate

Base Information

Chemical Name:diethyl N-ethyl-4-chloro-3-(4-phenyl-2-thiazolyl)anilinomethylenemalonate
CAS No.:134811-68-0
Molecular Formula:C₂₅H₂₅ClN₂O₄S
Molecular Weight:485.004
Hs Code.:

Synonyms:diethyl N-ethyl-4-chloro-3-(4-phenyl-2-thiazolyl)anilinomethylenemalonate

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Chemical Property of diethyl N-ethyl-4-chloro-3-(4-phenyl-2-thiazolyl)anilinomethylenemalonate

Chemical Property:

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Technology Process of diethyl N-ethyl-4-chloro-3-(4-phenyl-2-thiazolyl)anilinomethylenemalonate

There total 7 articles about diethyl N-ethyl-4-chloro-3-(4-phenyl-2-thiazolyl)anilinomethylenemalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 134811-66-8
2-(2-chloro-5-ethylamino)phenyl-4-phenylthiazole

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 134811-68-0
diethyl N-ethyl-4-chloro-3-(4-phenyl-2-thiazolyl)anilinomethylenemalonate

Guidance literature:: In toluene; Heating;
DOI:10.1002/jhet.5570280324

Reference yield:

: 16588-02-6
4-chloro-3-cyanonitrobenzene

: 134811-68-0
diethyl N-ethyl-4-chloro-3-(4-phenyl-2-thiazolyl)anilinomethylenemalonate

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Fe-powder, conc. HCl / ethanol; H₂O / Heating

2: 96 percent / CF₃CO₂H / Heating

3: 94 percent / H₂S, Et₃N, pyridine / 6 h / Ambient temperature

4: 81 percent / ethanol / Heating

5: K₂CO₃ / acetone / Heating

6: 10percent aq. NaOH / ethanol / Heating

7: 69 percent / toluene / Heating

With pyridine; hydrogenchloride; sodium hydroxide; hydrogen sulfide; iron; potassium carbonate; triethylamine; trifluoroacetic acid; In ethanol; water; acetone; toluene;
DOI:10.1002/jhet.5570280324

Reference yield:

: 35747-58-1
2-chloro-5-aminobenzonitrile

: 134811-68-0
diethyl N-ethyl-4-chloro-3-(4-phenyl-2-thiazolyl)anilinomethylenemalonate

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / CF₃CO₂H / Heating

2: 94 percent / H₂S, Et₃N, pyridine / 6 h / Ambient temperature

3: 81 percent / ethanol / Heating

4: K₂CO₃ / acetone / Heating

5: 10percent aq. NaOH / ethanol / Heating

6: 69 percent / toluene / Heating

With pyridine; sodium hydroxide; hydrogen sulfide; potassium carbonate; triethylamine; trifluoroacetic acid; In ethanol; acetone; toluene;
DOI:10.1002/jhet.5570280324