bis[(2-fluorophenyl)methyl] (1R,2S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylate

Base Information

Chemical Name:bis[(2-fluorophenyl)methyl] (1R,2S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylate
CAS No.:1311385-18-8
Molecular Formula:C₂₉H₃₀F₂N₄O₆S
Molecular Weight:600.643
Hs Code.:

Synonyms:bis[(2-fluorophenyl)methyl] (1R,2S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylate

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Chemical Property of bis[(2-fluorophenyl)methyl] (1R,2S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylate

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Technology Process of bis[(2-fluorophenyl)methyl] (1R,2S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylate

There total 5 articles about bis[(2-fluorophenyl)methyl] (1R,2S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311385-17-7
Bis[(2-fluorophenyl)methyl] (1S,2S,4S,5R,6R)-2-(tert-butoxycarbonylamino)-4-(p-tolylsulfonyloxy)bicyclo[3.1.0]hexane-2,6-dicarboxylate

: 3179-31-5
1H-[1,2,4]triazole-3-thiol

: 1311385-18-8
bis[(2-fluorophenyl)methyl] (1R,2S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; Inert atmosphere; Sealed tube;

Reference yield:

: 1311385-12-2
bis[(2-fluorophenyl)methyl] (1S,2S,5R,6R)-2-(tert-butoxycarbonylamino)-4-oxo-bicyclo[3.1.0]hexane-2,6-dicarboxylate

: 1311385-18-8
bis[(2-fluorophenyl)methyl] (1R,2S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: L-Selectride / tetrahydrofuran / 1.75 h / -78 °C / Inert atmosphere

1.2: -78 °C

2.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere; Sealed tube

With dmap; L-Selectride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1311385-14-4
(1S,2S,5R,6R)-2-(tert-butoxycarbonylamino)-4-oxo-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

: 1311385-18-8
bis[(2-fluorophenyl)methyl] (1R,2S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: L-Selectride / tetrahydrofuran / 1.75 h / -78 °C / Inert atmosphere

2.2: -78 °C

3.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

4.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere; Sealed tube

With dmap; L-Selectride; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;