(R)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

Base Information

Chemical Name:(R)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide
CAS No.:1454250-96-4
Molecular Formula:C₂₀H₁₃F₂N₃O₃S
Molecular Weight:413.404
Hs Code.:

Synonyms:(R)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

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Chemical Property of (R)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

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Technology Process of (R)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

There total 13 articles about (R)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454250-93-1
N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

: 1454250-96-4
(R)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

: 1454250-97-5
(S)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

Guidance literature:: With chiral SFC; In methanol; Resolution of racemate;

Reference yield:

: 99389-26-1
3,5-difluorobenzenethiol

: 1454250-96-4
(R)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

: 1454250-97-5
(S)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1.5 h / 100 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / chloroform / 2 h / 0 - 5 °C

3: hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 2.5 h / 20 °C

5: chiral SFC / methanol / Resolution of racemate

With hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1454252-73-3
5-[(3,5-difluorophenyl)sulfanyl]pyridin-2-carbonitrile

: 1454250-96-4
(R)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

: 1454250-97-5
(S)-N-([5-[(3,5-difluorobenzene)sulfinyl]pyridin-2-yl]methyl)furo[2,3-c]pyridin-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 2 h / 0 - 5 °C

2: hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 2.5 h / 20 °C

4: chiral SFC / methanol / Resolution of racemate

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; chloroform; N,N-dimethyl-formamide;