2-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one

Base Information

• Chemical Name: 2-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one
• CAS No.: 124909-82-6
• Molecular Formula: C₂₆H₂₄O₈
• Molecular Weight: 464.472
• Mol file: 124909-82-6.mol

Synonyms:2-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one

Chemical Property of 2-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one

There total 4 articles about 2-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1-(3,6-dihydroxy-2,4-dimethoxy-phenyl)-2-methoxy-ethanone (14639-73-7) + 3-benzyloxy-4-methoxy-benzoic acid-anhydride (59171-19-6) → 2-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one (124909-82-6)

Guidance literature:

With potassium 3-(benzyloxy)-4-methoxybenzoate;

DOI:10.1021/jm970842h

Reference yield:

3,5-dimethoxyphenol (500-99-2) → 2-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one (124909-82-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / HCl, ZnCl₂ / diethyl ether

2: 22 percent / K₂S₂O₈, NaOH / pyridine; H₂O

3: 52 percent / potassium 3-(benzyloxy)-4-methoxybenzoate

With hydrogenchloride; sodium hydroxide; dipotassium peroxodisulfate; potassium 3-(benzyloxy)-4-methoxybenzoate; zinc(II) chloride; In pyridine; diethyl ether; water;

DOI:10.1021/jm970842h

Reference yield:

2'-hydroxy-2,4',6'-trimethoxyacetophenone (17874-42-9) → 2-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one (124909-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 22 percent / K₂S₂O₈, NaOH / pyridine; H₂O

2: 52 percent / potassium 3-(benzyloxy)-4-methoxybenzoate

With sodium hydroxide; dipotassium peroxodisulfate; potassium 3-(benzyloxy)-4-methoxybenzoate; In pyridine; water;

DOI:10.1021/jm970842h

upstream raw materials:

1-(3,6-dihydroxy-2,4-dimethoxy-phenyl)-2-methoxy-ethanone

3-benzyloxy-4-methoxy-benzoic acid-anhydride

3,5-dimethoxyphenol

2'-hydroxy-2,4',6'-trimethoxyacetophenone

Downstream raw materials:

5,6-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-3,7-dimethoxy-chromen-4-one

3,4',5,6,7-pentahydroxy-3-methoxy-flavone

6-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,5,7-trimethoxychromen-4-one

5,6,3′-trihydroxy-3,7,4′-trimethoxyflavonol