1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

Base Information

• Chemical Name: 1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide
• CAS No.: 790691-53-1
• Molecular Formula: C₂₆H₃₂Cl₂N₈O₇S
• Molecular Weight: 671.561

Synonyms:1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

Chemical Property of 1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

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Technology Process of 1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

There total 2 articles about 1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

5'-N-ethyl-2',3'-O-isopropylidenecarboxamidoadenosine (39491-53-7) + N,N-bis(2-chloroethyl)-4-(isocyanato)benzenesulfonamide (790691-35-9) → 1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide (790691-53-1)

Guidance literature:

With TEA; In 1,4-dioxane; for 18h; Heating;

DOI:10.1021/jm0408161

Reference yield:

→ 1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide (790691-53-1)

Guidance literature:

Reference yield: 99.0%

1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide (790691-53-1) → 1-deoxy-1-[6-[[[(4-(bis-2-chloroethylaminosulfonyl)phenyl)amino]carbonyl]amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 65 ℃; for 1h;

DOI:10.1021/jm0408161

upstream raw materials:

5'-N-ethyl-2',3'-O-isopropylidenecarboxamidoadenosine

N,N-bis(2-chloroethyl)-4-(isocyanato)benzenesulfonamide

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