2-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]ethylcarbamoyl]benzoic acid

Base Information

• Chemical Name: 2-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]ethylcarbamoyl]benzoic acid
• CAS No.: 1268832-63-8
• Molecular Formula: C₄₆H₆₁N₅O₁₁
• Molecular Weight: 860.017

Synonyms:2-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]ethylcarbamoyl]benzoic acid

Chemical Property of 2-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]ethylcarbamoyl]benzoic acid

Chemical Property:

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Technology Process of 2-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]ethylcarbamoyl]benzoic acid

There total 6 articles about 2-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]ethylcarbamoyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H51N5O9 + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 2-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]ethylcarbamoyl]benzoic acid (1268832-63-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol200381z

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]ethylcarbamoyl]benzoic acid (1268832-63-8)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / Inert atmosphere

2: water; sodium hydroxide / ethanol / 20 h

3: tetrahydrofuran; acetonitrile / -70 - 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; acetonitrile / 0 - 20 °C / Inert atmosphere

With water; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

DOI:10.1021/ol200381z

Reference yield:

N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine (112-57-2) → 2-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-[tert-butoxycarbonyl-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]ethyl]amino]ethyl]amino]ethylcarbamoyl]benzoic acid (1268832-63-8)

Guidance literature:

Multi-step reaction with 5 steps

1: dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / Inert atmosphere

3: water; sodium hydroxide / ethanol / 20 h

4: tetrahydrofuran; acetonitrile / -70 - 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; acetonitrile / 0 - 20 °C / Inert atmosphere

With water; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

DOI:10.1021/ol200381z

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

di-tert-butyl dicarbonate

N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

N,N'-(((azanediylbis(ethane-2,1-diyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(2,2,2-trifluoroacetamide)

Downstream raw materials:

C₉₁H₁₃₈N₂₈O₁₁

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