methyl 5-((2-amino-4-bromo-phenyl)amino)-3-benzyloxy-2-thiophenecarboxylate

Base Information

Chemical Name:methyl 5-((2-amino-4-bromo-phenyl)amino)-3-benzyloxy-2-thiophenecarboxylate
CAS No.:959999-86-1
Molecular Formula:C₁₉H₁₇BrN₂O₃S
Molecular Weight:433.326
Hs Code.:

Synonyms:methyl 5-((2-amino-4-bromo-phenyl)amino)-3-benzyloxy-2-thiophenecarboxylate

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Chemical Property of methyl 5-((2-amino-4-bromo-phenyl)amino)-3-benzyloxy-2-thiophenecarboxylate

Chemical Property:

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Technology Process of methyl 5-((2-amino-4-bromo-phenyl)amino)-3-benzyloxy-2-thiophenecarboxylate

There total 6 articles about methyl 5-((2-amino-4-bromo-phenyl)amino)-3-benzyloxy-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929278-62-6
methyl 5-[(4-bromo-2-nitrophenyl)amino]-3-[(phenylmethyl)oxy]-2-thiophenecarboxylate

: 959999-86-1
methyl 5-((2-amino-4-bromo-phenyl)amino)-3-benzyloxy-2-thiophenecarboxylate

Guidance literature:: With hydrogen; 5 % platinum on sulfided carbon; In ethyl acetate; for 40h; under 2585.81 Torr;

Reference yield:

: 929278-60-4
methyl 5-amino-3-(benzyloxy)thiophene-2-carboxylate

: 959999-86-1
methyl 5-((2-amino-4-bromo-phenyl)amino)-3-benzyloxy-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 60 °C

2: hydrogen / 5 % platinum on sulfided carbon / ethyl acetate / 40 h / 2585.81 Torr

With hydrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5 % platinum on sulfided carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethyl acetate; 1: Suzuki Coupling;

Reference yield:

: 929278-58-0
methyl 3-(benzyloxy)-5-nitrothiophene-2-carboxylate

: 959999-86-1
methyl 5-((2-amino-4-bromo-phenyl)amino)-3-benzyloxy-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: iron; acetic acid / 2.5 h / 50 - 60 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 60 °C

3: hydrogen / 5 % platinum on sulfided carbon / ethyl acetate / 40 h / 2585.81 Torr

With hydrogen; iron; caesium carbonate; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5 % platinum on sulfided carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethyl acetate; 2: Suzuki Coupling;