3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy]propan-1-ol

Base Information

Chemical Name:3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy]propan-1-ol
CAS No.:892405-37-7
Molecular Formula:C₂₀H₂₅NO₂S
Molecular Weight:343.49
Hs Code.:

Synonyms:3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy]propan-1-ol

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Chemical Property of 3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy]propan-1-ol

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Technology Process of 3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy]propan-1-ol

There total 12 articles about 3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 3-[3-({[2-hydroxy-2-(4-methylsulfanylphenyl)ethyl](methyl)amino}methyl)phenoxy]propan-1-ol

: 892405-37-7
3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy]propan-1-ol

: 3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-5-yloxy]-propan-1-ol

Guidance literature:: With methanesulfonic acid; In dichloromethane; at 20 ℃; for 2h; regioselective reaction; Inert atmosphere; Cooling with ice;
DOI:10.1021/op700183q

Reference yield:

: 3-[2-methyl-4-(4-methylsulfanyl-phenyl)-1,2-dihydro-isoquinolin-7-yloxy]-propan-1-ol

: 892405-37-7
3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy]propan-1-ol

Guidance literature:: With sodium cyanoborohydride; In methanol; at 23 ℃; for 0.0833333h;
DOI:10.1016/j.bmcl.2006.11.036

Reference yield:

: 3-{3-[(E)-Methyliminomethyl]-phenoxy}-propan-1-ol

: 892405-37-7
3-[2-methyl-4-(4-methylsulfanylphenyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy]propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / NaBH₄ / methanol; H₂O / 18.5 h / 0 - 23 °C

2: (i-Pr)2NEt / tetrahydrofuran / 0.75 h / 23 °C

3: methanesulfonic acid / 18 h / 60 °C

4: NaCNBH₃ / methanol / 0.08 h / 23 °C

With sodium tetrahydroborate; methanesulfonic acid; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2006.11.036