ethyl 2-methyl-2-{2-methyl-4-[([4-(trifluoromethyl)benzyl]{6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}amino)methyl]phenoxy}propanoate

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Chemical Name:ethyl 2-methyl-2-{2-methyl-4-[([4-(trifluoromethyl)benzyl]{6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}amino)methyl]phenoxy}propanoate
CAS No.:637352-39-7
Molecular Formula:C₃₄H₃₂F₆N₂O₃
Molecular Weight:630.63
Hs Code.:

Synonyms:ethyl 2-methyl-2-{2-methyl-4-[([4-(trifluoromethyl)benzyl]{6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}amino)methyl]phenoxy}propanoate

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Chemical Property of ethyl 2-methyl-2-{2-methyl-4-[([4-(trifluoromethyl)benzyl]{6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}amino)methyl]phenoxy}propanoate

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Technology Process of ethyl 2-methyl-2-{2-methyl-4-[([4-(trifluoromethyl)benzyl]{6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}amino)methyl]phenoxy}propanoate

There total 5 articles about ethyl 2-methyl-2-{2-methyl-4-[([4-(trifluoromethyl)benzyl]{6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}amino)methyl]phenoxy}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 637352-39-7
ethyl 2-methyl-2-{2-methyl-4-[([4-(trifluoromethyl)benzyl]{6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}amino)methyl]phenoxy}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DME (dimethoxyethane) / 5 h / Heating / reflux

2: caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 70 °C

With sodium carbonate; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In DME (dimethoxyethane); toluene;

Reference yield:

: 15174-69-3
4-hydroxy-3-methyl-benzaldehyde

: 637352-39-7
ethyl 2-methyl-2-{2-methyl-4-[([4-(trifluoromethyl)benzyl]{6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}amino)methyl]phenoxy}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 42 h / 40 °C

2.1: dichloromethane / 0.5 h / 20 °C

2.2: 18 h

3.1: caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 70 °C

With caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; palladium diacetate; In DMF (N,N-dimethyl-formamide); dichloromethane; toluene;

Reference yield:

: 600-00-0
ethyl 2-bromoisobutyrate

: 637352-39-7
ethyl 2-methyl-2-{2-methyl-4-[([4-(trifluoromethyl)benzyl]{6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}amino)methyl]phenoxy}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 42 h / 40 °C

2.1: dichloromethane / 0.5 h / 20 °C

2.2: 18 h

3.1: caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 70 °C

With caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; palladium diacetate; In DMF (N,N-dimethyl-formamide); dichloromethane; toluene;