diethyl 2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetate

Base Information

• Chemical Name: diethyl 2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetate
• CAS No.: 1384276-71-4
• Molecular Formula: C₂₁H₂₄F₃N₃O₆
• Molecular Weight: 471.433
• Mol file: 1384276-71-4.mol

Synonyms:diethyl 2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetate

Chemical Property of diethyl 2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetate

There total 3 articles about diethyl 2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diethyl 2,2'-((5-(1-(hydroxyimino)ethyl)oxazol-2-yl)azanediyl)diacetate (1384276-70-3) + 4-bromomethyltrifluoromethylbenzene (402-49-3) → diethyl 2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetate (1384276-71-4)

Guidance literature:

With caesium carbonate; In hexane; N,N-dimethyl-formamide; at 25 ℃; for 18h; Inert atmosphere;

Reference yield:

5-acetyl-2-amino-oxazole (87005-17-2) → diethyl 2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetate (1384276-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 1 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide; hexane / 18 h / 25 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium acetate; caesium carbonate; In ethanol; hexane; water; N,N-dimethyl-formamide;

Reference yield:

diethyl 2,2'-((5-acetyloxazol-2-yl)azanediyl)diacetate (1384276-69-0) → diethyl 2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetate (1384276-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 1 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide; hexane / 18 h / 25 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium acetate; caesium carbonate; In ethanol; hexane; water; N,N-dimethyl-formamide;

upstream raw materials:

diethyl 2,2'-((5-(1-(hydroxyimino)ethyl)oxazol-2-yl)azanediyl)diacetate

4-bromomethyltrifluoromethylbenzene

5-acetyl-2-amino-oxazole

diethyl 2,2'-((5-acetyloxazol-2-yl)azanediyl)diacetate

Downstream raw materials:

2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)diacetic acid

2,2'-((5-(1-(((4-(trifluoromethyl)benzyl)oxy)imino)ethyl)oxazol-2-yl)azanediyl)bis(N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide)