2,6-pyridinedicarboxylic acid bis{N-ethyl-N-{5-{4-[N-6-(N,N-diethylcarbamoyl)pyridin-2-carbonyl-N-ethyl]amino}-3-nitrobenzyl}nitrophenyl}amide

Base Information

• Chemical Name: 2,6-pyridinedicarboxylic acid bis{N-ethyl-N-{5-{4-[N-6-(N,N-diethylcarbamoyl)pyridin-2-carbonyl-N-ethyl]amino}-3-nitrobenzyl}nitrophenyl}amide
• CAS No.: 561290-42-4
• Molecular Formula: C₆₃H₆₅N₁₃O₁₄
• Molecular Weight: 1228.29
• Mol file: 561290-42-4.mol

Synonyms:2,6-pyridinedicarboxylic acid bis{N-ethyl-N-{5-{4-[N-6-(N,N-diethylcarbamoyl)pyridin-2-carbonyl-N-ethyl]amino}-3-nitrobenzyl}nitrophenyl}amide

Chemical Property of 2,6-pyridinedicarboxylic acid bis{N-ethyl-N-{5-{4-[N-6-(N,N-diethylcarbamoyl)pyridin-2-carbonyl-N-ethyl]amino}-3-nitrobenzyl}nitrophenyl}amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-pyridinedicarboxylic acid bis{N-ethyl-N-{5-{4-[N-6-(N,N-diethylcarbamoyl)pyridin-2-carbonyl-N-ethyl]amino}-3-nitrobenzyl}nitrophenyl}amide

There total 3 articles about 2,6-pyridinedicarboxylic acid bis{N-ethyl-N-{5-{4-[N-6-(N,N-diethylcarbamoyl)pyridin-2-carbonyl-N-ethyl]amino}-3-nitrobenzyl}nitrophenyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2,6-Pyridinedicarbonyl dichloride (3739-94-4) + 6-(N,N-diethylcarbamoyl)-N-ethyl-N-{4'-[4''-(ethylamino)-3''-nitrobenzyl]-2'-nitrophenyl}pyridine-2-carboxamide (561290-40-2) → 2,6-pyridinedicarboxylic acid bis{N-ethyl-N-{5-{4-[N-6-(N,N-diethylcarbamoyl)pyridin-2-carbonyl-N-ethyl]amino}-3-nitrobenzyl}nitrophenyl}amide (561290-42-4)

Guidance literature:

With triethylamine; In dichloromethane; for 12h; Heating;

DOI:10.1002/chem.200390214

Reference yield:

6-(N,N-diethylcarbamoyl)pyridine-2-carboxylic acylchloride → 2,6-pyridinedicarboxylic acid bis{N-ethyl-N-{5-{4-[N-6-(N,N-diethylcarbamoyl)pyridin-2-carbonyl-N-ethyl]amino}-3-nitrobenzyl}nitrophenyl}amide (561290-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 950 mg / Et₃N / CH₂Cl₂ / 12 h / Heating

2: 84 percent / Et₃N / CH₂Cl₂ / 12 h / Heating

With triethylamine; In dichloromethane;

DOI:10.1002/chem.200390214

Reference yield:

2-(hydroxycarbonyl)-6-[(N,N-diethylamino)carbonyl]pyridine (179469-06-8) → 2,6-pyridinedicarboxylic acid bis{N-ethyl-N-{5-{4-[N-6-(N,N-diethylcarbamoyl)pyridin-2-carbonyl-N-ethyl]amino}-3-nitrobenzyl}nitrophenyl}amide (561290-42-4)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂; DMF / CH₂Cl₂ / 1.5 h / Heating

2: 950 mg / Et₃N / CH₂Cl₂ / 12 h / Heating

3: 84 percent / Et₃N / CH₂Cl₂ / 12 h / Heating

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1002/chem.200390214

upstream raw materials:

2,6-Pyridinedicarbonyl dichloride

6-(N,N-diethylcarbamoyl)-N-ethyl-N-{4'-[4''-(ethylamino)-3''-nitrobenzyl]-2'-nitrophenyl}pyridine-2-carboxamide

2-(hydroxycarbonyl)-6-[(N,N-diethylamino)carbonyl]pyridine