tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate

Base Information

• Chemical Name: tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate
• CAS No.: 476362-51-3
• Molecular Formula: C₁₇H₂₇F₂N₃O₃
• Molecular Weight: 359.416

Synonyms:tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate

Chemical Property of tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate

Chemical Property:

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Technology Process of tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate

There total 1 articles about tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-((2S,3S)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxy-4-(3,5-difluorophenyl)butyl)-2-ethylhydrazine-carboxylate (476362-50-2) → tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate (476362-51-3)

Guidance literature:

With hydrogen; 10% palladium on activated carbon; In methanol; for 4h;

Reference yield:

3-methyl-5-[(dipropylamino)carbonyl]benzoic acid (388072-25-1) + 3-methylbutyric acid (503-74-2) + tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate (476362-51-3) → N1-{(1S,2S)-1-(3,5-difluorobenzyl)-3-[l-ethyl-2-(3-methylbutanoyl)hydrazino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide (476360-96-0)

Guidance literature:

Reference yield:

3-methyl-5-[(dipropylamino)carbonyl]benzoic acid (388072-25-1) + tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate (476362-51-3) + 4-Methylpentanoic acid (646-07-1) → N1-{(1S,2S)-1-(3,5-difluorobenzyl)-3-[l-ethyl-2-(4-methylpentanoyl)hydrazino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide (476360-95-9)

Guidance literature:

upstream raw materials:

tert-butyl 2-((2S,3S)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxy-4-(3,5-difluorophenyl)butyl)-2-ethylhydrazine-carboxylate

Downstream raw materials:

N₁-{(1S,2S)-1-(3,5-difluorobenzyl)-3-[l-ethyl-2-(4-methylpentanoyl)hydrazino]-2-hydroxypropyl}-5-methyl-N₃,N₃-dipropylisophthalamide

N₁-{(1S,2S)-1-(3,5-difluorobenzyl)-3-[l-ethyl-2-(3-methylbutanoyl)hydrazino]-2-hydroxypropyl}-5-methyl-N₃,N₃-dipropylisophthalamide

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