(+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(4-chloro-2-methylphenyl)valinamide

Base Information

Chemical Name:(+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(4-chloro-2-methylphenyl)valinamide
CAS No.:936627-93-9
Molecular Formula:C₁₇H₂₅ClN₂O₃
Molecular Weight:340.85
Hs Code.:

(+)-(R)-N<sup>2</sup>-(tert-butoxycarbonyl)-N<sup>1</sup>-(4-chloro-2-methylphenyl)valinamide

Synonyms:(+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(4-chloro-2-methylphenyl)valinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(4-chloro-2-methylphenyl)valinamide

Chemical Property:

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Technology Process of (+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(4-chloro-2-methylphenyl)valinamide

There total 3 articles about (+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(4-chloro-2-methylphenyl)valinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 22838-58-0
Boc-D-Val-OH

: 95-69-2
4-chloro-2-methylbenzeneamine

: 936627-93-9
(+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(4-chloro-2-methylphenyl)valinamide

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In chloroform; for 6h; Heating;
DOI:10.1021/jm061078e

Reference yield:

: 640-68-6,25609-85-2,7004-03-7,921-10-8
D-Val-OH

: 936627-93-9
(+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(4-chloro-2-methylphenyl)valinamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / H₂O; dioxane / 20 °C

2: 35 percent / 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline; triethylamine / CHCl₃ / 6 h / Heating

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In 1,4-dioxane; chloroform; water;
DOI:10.1021/jm061078e

Reference yield:

: 73371-96-7
2-<<(tert-butoxycarbonyl)oxy>imino>-2-phenylacetonitrile

: 936627-93-9
(+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(4-chloro-2-methylphenyl)valinamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / H₂O; dioxane / 20 °C

2: 35 percent / 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline; triethylamine / CHCl₃ / 6 h / Heating

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In 1,4-dioxane; chloroform; water;
DOI:10.1021/jm061078e