4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine

Base Information

Chemical Name:4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine
CAS No.:14770-79-7
Molecular Formula:C₈H₁₁NS
Molecular Weight:153.248
Hs Code.:2934999090
DSSTox Substance ID:DTXSID40427999
Wikidata:Q82240763
Mol file:14770-79-7.mol

Synonyms:4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine;14770-79-7;4,5,6,7-tetrahydro-1-benzothiophen-2-amine;Benzo[b]thiophen-2-amine, 4,5,6,7-tetrahydro-;2-Amino-4,5,6,7-tetrahydrobenzothiophene;Benzo[b]thiophen-2-amine, 4,5,6,7-tetrahydro- (8CI,9CI);2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene;SCHEMBL5204253;DTXSID40427999;AC9731;MFCD07788347;AKOS015919697;SY251721;A884408

Suppliers and Price of 4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine 95+%
1g
$ 535.00

Chemenu
4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine 95%
1g
$ 505.00

American Custom Chemicals Corporation
4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-AMINE 95.00%
5MG
$ 505.48

AK Scientific
4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine
1g
$ 1207.00

Total 15 raw suppliers

Chemical Property of 4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine

Chemical Property:

Vapor Pressure:0.001mmHg at 25°C
Refractive Index:1.744
Boiling Point:313.15°C at 760 mmHg
PKA:3.13±0.20(Predicted)
Flash Point:143.188°C
PSA：54.26000
Density:1.294g/cm³
LogP:2.79030
Storage Temp.:2-8°C(protect from light)
Solubility.:Chloroform (Sligthly), Methanol (Slightly)
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:153.06122053
Heavy Atom Count:10
Complexity:126

Purity/Quality:

99%, ^*data from raw suppliers

4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2=C(C1)C=C(S2)N

Technology Process of 4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine

There total 5 articles about 4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5936-58-3
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

: 14770-79-7
2-amino-4,5,6,7-tetrahydrobenzothiophene

Guidance literature:: With oxalic acid; In isopropyl alcohol; at 35 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 105-56-6
ethyl 2-cyanoacetate

: 14770-79-7
2-amino-4,5,6,7-tetrahydrobenzothiophene

Guidance literature:: With sulfur; triethylamine; In ethanol; at 80 ℃; for 12h;
DOI:10.1016/j.ejmech.2020.112076

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 14770-79-7
2-amino-4,5,6,7-tetrahydrobenzothiophene

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur; morpholine; cyanoacetic acid tert-butyl ester / ethanol / 4 h / 40 °C

2: sodium hydroxide / ethanol / 2.5 h / Reflux

3: oxalic acid / isopropyl alcohol; acetone / 0.75 h / 38 °C

With morpholine; cyanoacetic acid tert-butyl ester; oxalic acid; sulfur; sodium hydroxide; In ethanol; isopropyl alcohol; acetone; 1: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.ejmech.2017.06.008