(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde

Base Information

Chemical Name:(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde
CAS No.:1400797-08-1
Molecular Formula:C₁₅H₁₂O₃
Molecular Weight:240.258
Hs Code.:

Synonyms:(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde

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Chemical Property of (S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde

Chemical Property:

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Technology Process of (S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde

There total 12 articles about (S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1400797-07-0
C₁₅H₁₁NO₂

: 1400797-08-1
(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -10 - 10 ℃; for 2h; Time; Temperature; Solvent; Inert atmosphere; Cooling;

Reference yield:

: 1400797-12-7
(±)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde

: 1400797-08-1
(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -10 - 10 ℃; for 2h; Inert atmosphere; Cooling;

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1400797-08-1
(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / acetone / 1 h / 25 °C / Inert atmosphere

2.1: dmap; triethylamine / tetrahydrofuran / 0.75 h / 40 °C / Inert atmosphere

3.1: formic acid-triethylamine complex / N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

4.1: water; lithium hydroxide monohydrate / methanol / 0.5 h / 60 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 - 25 °C / Inert atmosphere

6.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

7.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2.5 h / 0 - 25 °C / Inert atmosphere

7.2: 0 °C

With dmap; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; formic acid-triethylamine complex; water; diisobutylaluminium hydride; caesium carbonate; triethylamine; triphenylphosphine; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; toluene; 5.1: Mitsunobu reaction;