(E)-ethyl 2-(1-(2,4-dichlorobenzyl)-2-oxoindolin-3-ylidene)acetate

Base Information

• Chemical Name: (E)-ethyl 2-(1-(2,4-dichlorobenzyl)-2-oxoindolin-3-ylidene)acetate
• CAS No.: 1345838-02-9
• Molecular Formula: C₁₉H₁₅Cl₂NO₃
• Molecular Weight: 376.239
• Mol file: 1345838-02-9.mol

Synonyms:(E)-ethyl 2-(1-(2,4-dichlorobenzyl)-2-oxoindolin-3-ylidene)acetate

Chemical Property of (E)-ethyl 2-(1-(2,4-dichlorobenzyl)-2-oxoindolin-3-ylidene)acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-ethyl 2-(1-(2,4-dichlorobenzyl)-2-oxoindolin-3-ylidene)acetate

There total 1 articles about (E)-ethyl 2-(1-(2,4-dichlorobenzyl)-2-oxoindolin-3-ylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 1-(2,4-dichlorobenzyl)indoline-2,3-dione (79183-24-7) → (E)-ethyl 2-(1-(2,4-dichlorobenzyl)-2-oxoindolin-3-ylidene)acetate (1345838-02-9)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 0 - 20 ℃;

DOI:10.1021/ol202646w

Reference yield:

(E)-ethyl 2-(1-(2,4-dichlorobenzyl)-2-oxoindolin-3-ylidene)acetate (1345838-02-9) → (2'S,3'R)-ethyl 1-(2,4-dichlorobenzyl)-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate (1345838-34-7) + (2'S,3'S)-ethyl 1-(2,4-dichlorobenzyl)-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate + (2'R,3'R)-ethyl 1-(2,4-dichlorobenzyl)-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate (1345838-33-6) + (2'R,3'S)-ethyl 1-(2,4-dichlorobenzyl)-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate

Guidance literature:

With tert.-butylhydroperoxide; (S)-diphenylprolinol; In decane; hexane; at 25 ℃; for 96h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol202646w

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

1-(2,4-dichlorobenzyl)indoline-2,3-dione

Downstream raw materials:

(2'S,3'R)-ethyl 1-(2,4-dichlorobenzyl)-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate

(2'R,3'R)-ethyl 1-(2,4-dichlorobenzyl)-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate