(3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine

Base Information

Chemical Name:(3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine
CAS No.:1149380-86-8
Molecular Formula:C₁₆H₁₈N₄O₂
Molecular Weight:298.345
Hs Code.:

Synonyms:(3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine

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Chemical Property of (3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine

Chemical Property:

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Technology Process of (3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine

There total 9 articles about (3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.2%

: 1149381-00-9
3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)benzonitrile

: 1149380-86-8
(3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine

Guidance literature:: With ammonia; hydrogen; Raney-Ni; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1149380-86-8
(3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

2.1: sodium hydroxide; water / methanol / 4 h / 40 °C

3.1: thionyl chloride / 4 h / Reflux

3.2: 2 h / 20 °C

4.1: trichlorophosphate / 1,2-dichloro-ethane / 5 h / Reflux

5.1: N,N`-dimethylethylenediamine / toluene; hexane / 1 h / 0 - 20 °C / Inert atmosphere

5.2: 8 h / Inert atmosphere; Reflux

6.1: bromine / diethyl ether / 0 - 20 °C

7.1: ethanol / 5 h / Reflux

8.1: methanol / palladium on activated charcoal / 4 h / 20 °C

9.1: hydrogen; ammonium hydroxide / Raney-Ni / methanol / 3 h / 20 °C

With methanol; ammonium hydroxide; thionyl chloride; water; hydrogen; bromine; potassium carbonate; sodium hydroxide; N,N`-dimethylethylenediamine; trichlorophosphate; palladium on activated charcoal; In methanol; diethyl ether; ethanol; hexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 453565-77-0
methyl 3-cyano-5-(2-methoxyethoxy) benzoate

: 1149380-86-8
(3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N`-dimethylethylenediamine / toluene; hexane / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 8 h / Inert atmosphere; Reflux

2.1: bromine / diethyl ether / 0 - 20 °C

3.1: ethanol / 5 h / Reflux

4.1: methanol / palladium on activated charcoal / 4 h / 20 °C

5.1: hydrogen; ammonium hydroxide / Raney-Ni / methanol / 3 h / 20 °C

With methanol; ammonium hydroxide; hydrogen; bromine; N,N`-dimethylethylenediamine; palladium on activated charcoal; In methanol; diethyl ether; ethanol; hexane; toluene;