5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid methyl ester

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Chemical Name:5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid methyl ester
CAS No.:185399-85-3
Molecular Formula:C₂₃H₃₆O₄Si₂
Molecular Weight:432.707
Hs Code.:

Synonyms:5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid methyl ester

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Chemical Property of 5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid methyl ester

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Technology Process of 5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid methyl ester

There total 6 articles about 5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 17640-15-2
methyl cyanoformate

: 185399-84-2
4-(tert-Butyl-dimethyl-silanyloxy)-4-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohexanone

: 185399-85-3
5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(96)02009-6

Reference yield:

: 119951-16-5
(Z)-(4-chloro-3-buten-1-ynyl)trimethylsilane

: 185399-85-3
5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: n-Bu₃N, CuI / Pd4 / tetrahydrofuran / Ambient temperature

2: 2,6-lutidine / CH₂Cl₂ / -78 - 25 °C

3: 35 percent aq. CF₃CO₂H / CHCl₃ / Ambient temperature

4: 73 percent / LiHMSA, HMPA / tetrahydrofuran / -78 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; tributyl-amine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/S0040-4039(96)02009-6

Reference yield:

: 70097-74-4
8-ethynyl-1,4-dioxaspiro[4.5]decan-8-ol

: 185399-85-3
5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: n-Bu₃N, CuI / Pd4 / tetrahydrofuran / Ambient temperature

2: 2,6-lutidine / CH₂Cl₂ / -78 - 25 °C

3: 35 percent aq. CF₃CO₂H / CHCl₃ / Ambient temperature

4: 73 percent / LiHMSA, HMPA / tetrahydrofuran / -78 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; tributyl-amine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/S0040-4039(96)02009-6