3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cyclopentene

Base Information

• Chemical Name: 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cyclopentene
• CAS No.: 913289-99-3
• Molecular Formula: C₁₅H₁₇F₂NO₃
• Molecular Weight: 297.302
• Mol file: 913289-99-3.mol

Synonyms:3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cyclopentene

Chemical Property of 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cyclopentene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cyclopentene

There total 3 articles about 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 6-chloro-5,5-difluoro-6-(4-methoxyphenylimino)-hexanoate → 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cyclopentene (913289-99-3)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1021/ol061892w

Reference yield: 80.0%

C15H18ClF2NO3 (913289-96-0) → 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cyclopentene (913289-99-3)

Guidance literature:

C₁₅H₁₈ClF₂NO₃; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1021/jo900296d

Reference yield:

ethyl 6-chloro-5,5-difluoro-6-(4-methoxyphenylimino)-2-hexenoate → 3,3-difluoro-1-(ethoxycarbonyl)-2-(4-methoxyphenylamino)-1-cyclopentene (913289-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / hydrogen / Pd/C / ethyl acetate / 24 h / 25 °C / 3040 Torr

2: 80 percent / LDA / tetrahydrofuran; hexane / 1 h / -78 °C

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; hexane; ethyl acetate; 2: Dieckmann condensation;

DOI:10.1021/ol061892w

upstream raw materials:

C₁₅H₁₈ClF₂NO₃