(S)-1,3-di(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Base Information

Chemical Name:(S)-1,3-di(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea
CAS No.:1450733-50-2
Molecular Formula:C₃₁H₃₉N₃O₅
Molecular Weight:533.668
Hs Code.:

Synonyms:(S)-1,3-di(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

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Chemical Property of (S)-1,3-di(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

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Technology Process of (S)-1,3-di(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

There total 3 articles about (S)-1,3-di(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1450733-39-7
(S)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

: 131362-25-9
[3-(bromomethyl)-phenoxy]dimethyl(1,1-dimethylethyl)silane

: 1450733-47-7
(S)-1-(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

: 1450733-50-2
(S)-1,3-di(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.06.018

Reference yield:

: 19438-10-9
methyl 3-hydroxybenzoate

: 1450733-50-2
(S)-1,3-di(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

2.2: Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.06.018

Reference yield:

: 120687-94-7
3-t-butyldimethylsilyloxybenzoic acid methyl ester

: 1450733-50-2
(S)-1,3-di(3-hydroxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

1.2: Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.06.018