2-Methyl-3-(4-oxo-cyclohexa-2,5-dienylideneamino)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one; compound with acetic acid

Base Information

• Chemical Name: 2-Methyl-3-(4-oxo-cyclohexa-2,5-dienylideneamino)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one; compound with acetic acid
• CAS No.: 80381-75-5
• Molecular Formula: C₂H₄O₂*C₁₉H₁₃N₃O₂S
• Molecular Weight: 407.45
• Mol file: 80381-75-5.mol

Synonyms:2-Methyl-3-(4-oxo-cyclohexa-2,5-dienylideneamino)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one; compound with acetic acid

Chemical Property of 2-Methyl-3-(4-oxo-cyclohexa-2,5-dienylideneamino)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one; compound with acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-3-(4-oxo-cyclohexa-2,5-dienylideneamino)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one; compound with acetic acid

There total 2 articles about 2-Methyl-3-(4-oxo-cyclohexa-2,5-dienylideneamino)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one; compound with acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-amino-2-methyl-5-phenyl-3H-thieno-[2,3-d]pyrimidin-4-one (43088-51-3) + p-benzoquinone (106-51-4) → 2-Methyl-3-(4-oxo-cyclohexa-2,5-dienylideneamino)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one; compound with acetic acid (80381-75-5)

Guidance literature:

With acetic acid; for 20h; Ambient temperature;

DOI:10.1007/BF00760666

Reference yield:

2-acetylamino-4-phenyl-thiophene-3-carboxylic acid ethyl ester (13130-37-5) → 2-Methyl-3-(4-oxo-cyclohexa-2,5-dienylideneamino)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one; compound with acetic acid (80381-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 26 percent / hydrazine hydrate / 6 h / Heating

2: 60 percent / 60percent aq. CH₃COOH / 20 h / Ambient temperature

With hydrazine hydrate; acetic acid;

DOI:10.1007/BF00760666

Reference yield: 79.4%

2-Methyl-3-(4-oxo-cyclohexa-2,5-dienylideneamino)-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one; compound with acetic acid (80381-75-5) → 3-(4-Hydroxy-phenylamino)-2-methyl-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one (80381-81-3)

Guidance literature:

With sodium disulfite; In 1,4-dioxane; for 0.25h; Ambient temperature;

DOI:10.1007/BF00760666

upstream raw materials:

3-amino-2-methyl-5-phenyl-3H-thieno-[2,3-d]pyrimidin-4-one

p-benzoquinone

2-acetylamino-4-phenyl-thiophene-3-carboxylic acid ethyl ester

Downstream raw materials:

3-(4-Hydroxy-phenylamino)-2-methyl-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one