[S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide

Base Information

Chemical Name:[S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide
CAS No.:1073923-27-9
Molecular Formula:C₂₅H₃₆F₃N₃O₅S₂
Molecular Weight:579.705
Hs Code.:

Synonyms:[S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide

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Chemical Property of [S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide

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Technology Process of [S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide

There total 1 articles about [S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 952506-23-9
[S(S)]-N-[(1R)-1-(3-exo)-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide

: 78374-13-7
(morpholine-4-sulfonyl)-acetic acid

: 1073923-27-9
[S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide

Guidance literature:: With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In ethyl acetate; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo801830x

Reference yield: 72.0%

: 1073923-27-9
[S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide

: 1-{3-[(R)-1-amino-2-(2,4,5-frifluorophenyl)ethyl]-8-azabicyclo[3.2.1]oct-8-yl}-2-(morpholine-4-sulfonyl)ethanone

Guidance literature:: [S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide; With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1021/jo801830x