3,5-Dimethyl-adamantane-1-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

Base Information

Chemical Name:3,5-Dimethyl-adamantane-1-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester
CAS No.:594836-38-1
Molecular Formula:C₃₀H₃₉NO₄S₂
Molecular Weight:541.776
Hs Code.:

Synonyms:3,5-Dimethyl-adamantane-1-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

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Chemical Property of 3,5-Dimethyl-adamantane-1-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

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Technology Process of 3,5-Dimethyl-adamantane-1-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

There total 4 articles about 3,5-Dimethyl-adamantane-1-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 312692-99-2
3,5-dimethyl-1-adamantylzinc bromide

: 446021-62-1
(2S,3aR,8aS)-3-(mesitylsulfonyl)-3,3a,8,8a-tetrahydroindeno[1,2-d][1,2,3]oxathiazole-2-oxide

: 594836-38-1
3,5-Dimethyl-adamantane-1-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

Guidance literature:: In tetrahydrofuran; at -45 - 0 ℃;
DOI:10.1016/j.tet.2005.03.122

Reference yield:

: 861821-86-5
2-Methyl-propane-2-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

: 594836-38-1
3,5-Dimethyl-adamantane-1-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -45 °C

1.2: tetrahydrofuran; hexane / -78 - -75 °C

2.1: 80 percent / thionyl chloride; 3,5-lutidine / tetrahydrofuran / -45 °C

3.1: 83 percent / tetrahydrofuran / -45 - 0 °C

With 3,5-Lutidine; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2005.03.122

Reference yield:

: 446021-63-2
(2S,3aR,8aS)-3-(2,4,6-Trimethyl-benzenesulfonyl)-3,3a,8,8a-tetrahydro-1-oxa-2-thia-3-aza-cyclopenta[a]indene 2-oxide

: 594836-38-1
3,5-Dimethyl-adamantane-1-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / tetrahydrofuran / -20 - 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -45 °C

2.2: tetrahydrofuran; hexane / -78 - -75 °C

3.1: 80 percent / thionyl chloride; 3,5-lutidine / tetrahydrofuran / -45 °C

4.1: 83 percent / tetrahydrofuran / -45 - 0 °C

With 3,5-Lutidine; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2005.03.122