3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester

Base Information

Chemical Name:3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester
CAS No.:335161-37-0
Molecular Formula:C₂₅H₄₄O₅Si₂
Molecular Weight:480.792
Hs Code.:

3-[3,4-bis-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester

Synonyms:3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester

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Chemical Property of 3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester

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Technology Process of 3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester

There total 2 articles about 3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 335161-36-9
3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-but-3-enyl ester

: 335161-37-0
3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester

Guidance literature:: With sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; at 20 ℃; for 2h;
DOI:10.1021/jo005763j

Reference yield:

: 116511-71-8
3,4-bis(O-tert-butyldimethylsilyl)-3,4-dihydroxyhydrocinnamic acid

: 335161-37-0
3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / DCC; DMAP / CH₂Cl₂ / 2 h / 20 °C

2: 77 percent / OsO₄; NaIO₄ / dioxane; H₂O / 2 h / 20 °C

With dmap; sodium periodate; osmium(VIII) oxide; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo005763j

Reference yield:

: 335161-37-0
3-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 1-methyl-3-oxo-propyl ester

: 71939-67-8
(R)-1-methyl-2-[(S)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl 3-(3,4-dihydroxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether; pentane / 1 h / -100 °C

1.2: NaOH; H₂O₂ / methanol

2.1: Et₃N / CH₂Cl₂ / 4 h / 20 °C

3.1: 2.53 g / (Cy₃P)2Cl₂Ru=CHPh / CH₂Cl₂ / 12 h / Heating

4.1: 80 percent / benzoic acid; TBAF / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; benzoic acid; Grubbs catalyst first generation; In tetrahydrofuran; diethyl ether; dichloromethane; pentane;
DOI:10.1021/jo005763j