1-ethyl-3-(4-((6S,9R)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-2-yl)phenyl)urea

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Chemical Name:1-ethyl-3-(4-((6S,9R)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-2-yl)phenyl)urea
CAS No.:1428902-68-4
Molecular Formula:C₂₃H₃₀N₆O₂
Molecular Weight:422.53
Hs Code.:

Synonyms:1-ethyl-3-(4-((6S,9R)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-2-yl)phenyl)urea

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Chemical Property of 1-ethyl-3-(4-((6S,9R)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-2-yl)phenyl)urea

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Technology Process of 1-ethyl-3-(4-((6S,9R)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-2-yl)phenyl)urea

There total 8 articles about 1-ethyl-3-(4-((6S,9R)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1428902-80-0
(6S,9R)-2,2,2-trichloroethyl 2-(4-(3-ethylureido)phenyl)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

: 1428902-68-4
1-ethyl-3-(4-((6S,9R)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: With ammonium acetate; zinc; In tetrahydrofuran; water; at 20 ℃; for 48h;
DOI:10.1021/jm400194n

Reference yield:

: C₁₈H₂₁Cl₃N₂O₃

: 1428902-68-4
1-ethyl-3-(4-((6S,9R)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 7.17 h / 0 - 25 °C

2: 2-chloropyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.68 h / -78 - 25 °C

3: ammonium chloride; iron / ethanol; water / 2 h / Reflux

4: triethylamine / tetrahydrofuran / 25 °C

5: zinc; ammonium acetate / water; tetrahydrofuran / 48 h / 20 °C

With 2-chloropyridine; trifluoromethylsulfonic anhydride; ammonium acetate; iron; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm400194n

Reference yield:

: 1428902-78-6
(6S,9R)-2,2,2-trichloroethyl 4-((S)-3-methylmorpholino)-2-(4-nitrophenyl)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidine-10-carboxylate

: 1428902-68-4
1-ethyl-3-(4-((6S,9R)-4-((S)-3-methylmorpholino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; iron / ethanol; water / 2 h / Reflux

2: triethylamine / tetrahydrofuran / 25 °C

3: zinc; ammonium acetate / water; tetrahydrofuran / 48 h / 20 °C

With ammonium acetate; iron; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm400194n